Cardiovascular and Renal Effects of Hibiscus Sabdariffa Linnaeus. in Patients with Diabetic Nephropathy: A Randomized, Double-Blind, Controlled Trial

Authors

  • Akram Esmaeili Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Azadeh Nadjarzadeh Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Hassan Mozaffari-Khosravi Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  • Javad Zavar Reza Department of Medical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mohammad Mohammadi Department of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  • Nahid Ramezani-Jolfaie Department of Community Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Roya Hemayati Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Roya Sakhaei Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:

Background: Hibiscus sabdariffa linnaeus (HSL) is a tropical plant with a high content of anthocyanin, traditionally found to have beneficial biological activities. This randomized, double-blind, placebo-controlled, and parallel trial was conducted to assess some renal and cardiovascular effects of supplementation with HSL in patients with diabetic nephropathy. Methods: The study protocol was completed by 60 patients (38 females and 22 males) who were randomly assigned into the supplemented (SG) and Placebo groups (PG). The SG was treated with 425 mg of HSL twice daily and the PG received the placebo. Anthropometric and dietary information as well as fasting blood and urine samples were collected at the baseline and end of an 8-week intervention period. Results: Compared with the PG, supplementation with HSL significantly reduced systolic blood pressure (P = 0.01) and high-sensitivity C-reactive protein (P = 0.004). A significant increase was observed in total antioxidant capacity levels in the SG (P = 0.03). Moreover, we found a significant reduction in the levels of blood urea nitrogen (P < 0.001), blood creatinine (P = 0.002), urine creatinine (P < 0.001), and urine albumin (P < 0.001) in the SG compared with the PG. However, no significant change was observed in diastolic blood pressure, fasting blood glucose, and glomerular filtration rate following intervention between two groups. Conclusions: HSL supplementation seems to be beneficial in improving the outcomes of patients with diabetic nephropathy; however, no considerable effect was observed on fasting glucose levels. Large-scale trials are needed to better understand its efficiency and safety for long-term use.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effects of Nigella sativa L. Seed Oil in Type II Diabetic Patients: a Randomized, Double-Blind, Placebo - Controlled Clinical Trial

Background: Nigella sativa (N. sativa) seeds are used to treat diabetes mellitus in traditional medicine. Moreover, N. sativa oil has reduced the fasting blood glucose level in non-diabetic volunteers. Objective: The present study was undertaken to explore the possible anti-hyperglycemic effect of N. sativa oil in type II diabetic patients. Methods: A randomized clinical trial was conducted ...

full text

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy

OBJECTIVE To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy. RESEARCH DESIGN AND METHODS Patients with type 2 diabetes and UAE equivalent to 15-300 mg/24 h, despite ACE inhibitors (ACE-Is) or angiotensin receptor blockers (ARBs), were randomly assigned to ...

full text

Effect of acupressure on constipation in patients undergoing hemodialysis: A randomized double-blind controlled clinical trial

Objective: Constipation is one of the most common digestive problems in patients undergoing hemodialysis. It has a negative effect on quality of life in these patients. As routine treatments are not effective in this regard, complementary therapies may help to overcome this condition. This study aimed to investigate the effect of acupressure on constipation in patients undergoing hemodialysis. ...

full text

Effect of Memantine on Positive Sign in Patients with Schizophrenia and Schizoaffective Disorders: A Randomized Double Blind Placebo Controlled Trial

Background and purpose: Memantine is a medication used to treat moderate to severe Alzheimer’s disease. Memantine targeting the glutamatergic system specifically N-Methyl-D-Aspartate offer a novel approach in treatment of psychiatric disorders such as schizophrenia and schizoaffective disorder. The purpose of this study was to evaluate the efficacy and safety of memantine in combination with an...

full text

Cynara scolymus L. in Treatment of Hypercholesterolemic Type 2 Diabetic Patients: a Randomized Double-Blind Placebo-Controlled Clinical Trial

Background: Type 2 diabetes mellitus with hyperlipidemia is a common disease. Conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. Previous studies suggest that fiber-free artichoke (Cynara scolymus L.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholest...

full text

Cicer arietinum in the Treatment of Small Renal Stones: a Double-Blind, Randomized and Placebo-Controlled Trial

Background and objectives: Urolithiasis is a common urological disorder. Based on the Persian medicine literatures, Cicer arietinum has a potential to dissolve renal stones. This study was designed to assess the efficacy and safety of Cicer arietinum in patients with renal stone. Methods: The extract of C. arietinum seeds was sp...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 2

pages  116- 126

publication date 2021-05

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023